Murcia, the capital of the region, is located inland. Murcia has a small downtown area out of which rises the cathedral spire over its blue ceramic domes. The cathedral is, in fact, the principal building. It was built over the Aljama mosque constructed when Murcia was under Mohammedan rule. It was begun in 1394 and dedicated in 1465. Its principal facade was constructed by Jaime Bort from 1737 to 1754. It is a splendid and sumptuous example of Baroque architecture which resembles an allegorical retable in which the sculpture plays the most important part. The Gothic Apostles Door dates from the 15th century and the Gothic chapel inside the cathedral has been declared a national monument, together with the Plateresque Junterones chapel. The 95 meter tower exhibits the three periods of its construction: Renaissance, Herrerian and Baroque, and finally the Neoclassic belfry, the work of Ventura Rodriguez. In the main altar chapel there is the urn which holds the heart of Alfonso X which the Wise King willed to his town.

Other buildings of interest in Murcia are the Bishop's Palace, 18th century, the Church de la Merced, with its beautiful Baroque portal, and the university next to it, and the Church of Jesus, today a Museum where the works of Salzillo, a great Murcian artist, are kept.